Metabolomics Applications

Central to metabolomics is the aim of identifying potential small molecule biomarkers that correlate to a disease, drug toxicity, or genetic or environmental variation. Metabolomics has a high impact on the way how research is conducted in many application areas.

经过验证的临床研究或公共卫生研究中的生物标志物可以构成新的诊断测定方法的基础，并为帮助建立真正的个性化医学的方式带来了道路。

Metabolomics applied in pharmaceutical research can provide early information on drug toxicity, one central aim in pharmaceutical discovery.

功能性基因组学研究对细菌，植物，动物和人类研究中的基因功能和相互作用受益于代谢分析方法受益，因为小分子浓度的变化与观察到的表型密切相关。在营养和食品中应用的代谢组学彻底改变了食物掺假的检测，并协助育种者进行战略特征优化。

同样，对于您的代谢组学应用程序，布鲁克（Bruker）提供了类领先的解决方案，以基于连字符NMR，LC-MS，GC-MS和FT-IR Technologies的最新创新来生成答案。

在临床研究中，代谢组学策略应用于模型系统，例如细胞培养物或动物，直到大规模流行病学研究，因为这些方法具有检测新的生物标志物的巨大潜力。经过验证的生物标志物可以在诊断和监测药物疗法中服务 - 最终使实际的perzonalization药物能够。

经过验证的生物标志物还将阐明疾病的分子基础，并指出新的药物靶标，这在药物研究中至关重要。

One example for the impact of metabolomics in human health studies is an extremely promising project in NMR based analysis helping to deliver efficient, reliable screening of inborn errors in newborn health. It has the potential to generate a push-button, high throughput screening solution offering simultaneous non-targeted and targeted analysis.

In addition to NMR, Bruker´s LC-MS, and GC-MS based metabolomics solutions perfectly match the requirements for comprehensive metabolic profiling, sample throughput, biomarker detection, identification, validation and quantification.

分子或分子类别从药物开发管道中损失的后来，财务成本越高。因此，最小化损耗是药物发现计划的最重要目标之一。

Novel technologies that increase the probability of making the right choice early save resources, and promote safety, efficacy and profitability.

代谢组学是一种研究体内代谢谱的系统方法，该方法有望在发现和开发过程的多个阶段提供有关药物毒性，疾病过程和基因功能的信息。

Pharma, Metabolomics, Phenomics, Exposomics and non-targeted screening have different aims. But with that said, all these disciplines share some common needs, like rapid de-replication of compounds of interest (drug metabolites, possible live style or environmental exposure markers).

集成软件解决方案MetaboScape^®解决了推进药物，代谢组学，脂质组学，非目标筛查和外向性研究的共同需求：

• Local metabolite prediction by BioTransformer¹enables secure drug metabolite annotation in MetaboScape^®
• Support for multifactorial time-course experiments in MetaboScape® supports semi-quantitative description of metabolic pathways in drug metabolism and spend media analysis for (Bio)pharma research

从原材料到最终的消必威手机客户端费产品，对生产者，消费者和监管机构的安全性，真实性和食品质量的监测至关重要。为了实现这一目标，需要精确，准确的分析工具，以确保食物的起源，特性，伪造和可靠性。基于NMR的JUICESCREENER是Bruker在果汁评估中使用推送按钮解决方案如何应用目标和非目标的多标记分析来解决这种需求的完美示例。

In addition to food control, metabolomics approaches are successfully applied in food and nutrition trait optimization. In particular metabolomics based research to enhance nutrition and taste characteristics holds great potential for the agricultural industry. Targeted as well as non-targeted metabolomics approaches are readily enabled by Bruker´s product portfolio for comprehensive small molecule profiling based on complementary LC-MS, GC-MS, NMR and FT-IR technology.

Metabolomics has a huge impact on plant physiology research. Although „classical“ plant biochemistry has been studied for many decades, the holistic approach of metabolic profiling found its way in many research groups.

一道方法可以提供重要的信息rmation on unexpected metabolic changes induced in plants by biotic or abiotic factors as well as in unraveling gene functions in functional genomics studies.

布鲁克的代谢组学解决方案很容易启用这些非目标和目标方法。特别是，NMR，LC-MS和GC-MS等互补技术的结合完美地解决了对小分子进行全面分析的需求。

代谢组学工作流的一个不可或缺的一部分是Bruker量身定制的软件，可快速查明相关信息并生成知识。

Microorganisms have a long-standing tradition as a source of biologically active small molecules – termed “secondary metabolites“. Besides activity-guided isolation, metabolomics based strategies are becoming increasingly successful in revealing additional natural products. These approaches hold great promise for uncovering novel secondary metabolites from bacterial and fungal strains. Examples for biologically active compounds are novel antibiotics to target resistant pathogens.

微生物用于生物活性小分子的工业尺度产生，以及其他靶标化必威东盟体育合物，例如氨基酸和所使用的维生素，例如补充食物。为了增加所需产品代谢组学的产生，通常将基于基因工程的直接菌株设计应用于直接的合理菌株设计。这种方法通常与功能基因组学研究息息相关，以阐明基础研究中的基因功能。总而言之，代谢组学已成为微生物研究中不可或缺的一部分。

布鲁克’sLC-MS，，，，GC-MSandNMRbased metabolomics solutions perfectly match the requirements for comprehensive metabolic profiling, sample throughput, compound identification, validation and quantification.