细胞融合300
强调
CellHesion® 300
自动化Cellhesion®300是测量具有单分子灵敏度的细胞细胞，细胞 - 组织和细胞基底相互作用的理想工具。它可以快速，轻松地测量活生物系统的结构，形态和纳米力学特性，从而对它们在各种病理疾病中所起的作用产生关键见解。这种创新的系统为生物物理学，生物化学，植入物研究，伤口愈合，发育生物学，干细胞研究，感染生物学和免疫反应研究创造了新的可能性。
特征
Understanding Biomechanics Made Easy
细胞融合300provides reproducible, quantitative data of unprecedented quality. Its high degree of automation increases throughput and delivers the productivity, performance, and statistical significance required for biomedical and clinical research environments. Important parameters, such as maximum adhesion force, individual unbinding events, and tether characteristics are automatically determined from each dataset by innovative software solutions.
Only CellHesion 300 delivers:
- Maximized throughput for higher productivity by automating measurements
- 在近生物生理条件下，活样品的相关和无标签的多参数测量
- Fast and simple selection of regions of interest over large sample areas, ideal for tissue biopsies
- 具有视觉支持的系统工作流程
"Automatic mechanical screening of highly topographic samples with the CellHesion 300 is of great advantage for tissue characterization in the clinical context."
Prof. Dr. Ansgar Petersen
BIH, Center for Regenerative Therapies
德国柏林Charité医科大学
Performing Automated Multi-Parametric Nanomechanical Mapping
最先进的软件，直观的用户指导和检测系统的自动对齐为自动操作和快速结果的关键。
新的Cell Hishion 300用户界面可快速简便地控制系统及其操作参数。
The software offers an easy-to-use scripting tool for user-defined experiments. Powerful batch data processing capabilities enable the analysis and quantification of large datasets at the touch of a button.
Discover the Possibilities
具有较大地形范围的样品的粘弹性特性的映射，具有可选的Z-Scanner和NestedScanner功能的扩展频率尺度
在近生物生理条件下研究活细胞，并具有广泛的配件，以控制环境条件，例如温度和CO2levels
Automate Investigation of Large Samples
新的SmartMapping功能可以选择灵活的，用户定义的2D形力图。通过新的大型Z-MOTOR进行连续评估并自动调整力的最佳力量采集范围。使用光学瓷砖，可以提前选择多个感兴趣的领域并自动检查，从而可以轻松有效地研究大型样品领域。改进的电动阶段精度可授予一定程度的精度和速度。
Integrate Seamlessly with Optical Microscopes
细胞融合300can be seamlessly integrated into the latest research grade optical microscopes with advanced and super-resolution capabilities, to deliver real-time, correlative data sets for the comprehensive characterization of living biological samples. Versatile experimental setups and automated adjustment
系统参数为长期自我调节实验系列开辟了新的可能性。细胞融合300是研究粗糙表面，密集堆积的细胞层和高度波纹组织样品的理想解决方案。
使用细胞融合技术选择科学出版物
- Abuhattum et al., Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens. Sci Rep 12, 10325 (2022).
- Michael et al., Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy. Nat Protoc 16, 2418–2449 (2021).
- Liebsch et al., Quantification of heparin’s antimetastatic effect by single-cell force spectroscopy. J Mol Recognit. 34, e2854 (2021).
- Möllmert et al., Zebrafish Spinal Cord Repair Is Accompanied by Transient Tissue Stiffening. Biophys J. 118(2), 448-463 (2020).
- Shen et al., Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer. Cancer Cell 37(6), 800-817 (2020).
- Rheinlaender等人，皮质细胞刚度与底物力学无关，NAT。母校。19，1019-1025（2020）。
- 亚伦at al., Quantification of heparin's antimetastatic effect by single-cell force spectroscopy, J Mol Recognit., 1–11 (2020).
- Krieg et al., Atomic force microscopy- based Mechanobiology, Nature Reviews Physics 1, 41–57 (2019)
- Stylianou et al., Review Article: Atomic Force Microscopy on Biological Materials Related to Pathological Conditions, Andreas, Scanning, 8452851 (2019)
- Thompson等人，组织力学的快速变化调节发育中的胚胎大脑中的细胞行为。Elife 8：E39356（2019）
- Miroshnikova et al., Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification, Nat Cell Biol 20, 69–80 (2018)
- Elias et al., Tissue stiffening coordinates morphogenesis by triggering collective cell migration体内，Nature 554，523-527（2018）
- Bharadwaj et al., aV-class integrins exert dual roles on a5b1 integrins to strengthen adhesion to fibronectin, Nature Communications 8, 14348, 1-10 (2017)
- Friedrichs et al., A practical guide to quantify cell adhesion using single-cell force spectroscopy. Methods (2013)
Applications
CellHesion Data Gallery
Bruker的Bioafms允许生命科学和生物物理学研究人员在细胞力学和粘附，机械生物学，细胞细胞和细胞表面相互作用，细胞动力学和细胞形态中进一步研究。我们收集了一个图像的画廊，展示了其中一些应用程序。
Specifications
配件
The Widest Range of Accessories in the Market
Optical systems/accessories, electrochemistry solutions, electrical sample characterization, environmental control options, software modules, temperature control, acoustic and vibration isolation solutions and more. Bruker provides you with the right accessories to control your sample conditions and to perform successful experiments.
网络研讨会
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