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强调

1.2 GHz

布鲁克’s novel UHF NMR magnet technology makes it possible to achieve magnetic flux densities of 28.2 Tesla, which corresponds to a proton resonance frequency of 1.2 GHz

Hybrid

力量的1.1和1.2 GHz核磁共振磁体利用11月el hybrid design with advanced high-temperature superconductor (HTS) in the inner sections and low-temperature superconductor (LTS) in the outer sections of the magnet.

高分辨率

布鲁克’s 1.1 and 1.2 GHz spectrometers have been optimized for high resolution NMR experiments. The exquisite field homogeneity and temporal field stability surpass other high field magnets, e.g. driven mode systems.

For many years, high-resolution NMR was limited to a magnetic field of 23.5 Tesla, equivalent to a proton resonance frequency of 1.0 GHz. This limit was set by the physical properties of metallic, low-temperature superconductors (LTS), and it was first reached in 2009 with an Avance® 1000 spectrometer at the Ultra-High Field NMR Center in Lyon, France.

高温超导体（HTS）于1980年代首次发现，在低温下打开了更高磁场的大门，但在YBCO HTS磁带制造和超导磁铁技术中，巨大的挑战使UHF进一步越来越令人生畏。

布鲁克（Bruker）独特的1.1和1.2 GHz NMR磁铁利用内部截面中的高级高温超导体（HTS）和低温超导体（LTS）的新型混合设计，并在磁铁外部的低温超导体（LTS）中。Ascend 1.1和1.2 GHz是稳定的标准孔（54毫米）磁体，具有精致的同质性和与高分辨率NMR的要求要求相吻合的均匀性和田间稳定性。1.2 GHz光谱仪可提供不同的超高场探针，包括用于溶液状态NMR的冷冻探针，可快速旋转MAS固态NMR探针。

Caption: Artist’s impression of a UHF NMR magnet. The solenoid magnet consists of several concentrically arranged magnet sections made from different superconducting materials. NbTi (yellow) is used in the outermost sections of the magnet, Nb3Sn (red) in the mid-field region, and high-temperature superconductors (blue) in the central section. Cryogenic shim coils are used to improve the homogeneity of the magnetic field. Operation with a persistent ensures that the magnetic field is very stable over time

Bruker GHz级NMR用于功能结构生物学研究

布鲁克（Bruker）通过高级NMR解决方案帮助阐明功能结构生物学研究。新型的GHz级NMR技术可以使高级研究对蛋白质 - 配体相互作用的亲和力和特异性的结构基础，包括对细胞膜蛋白的结构特征的更好理解，以及涉及蛋白质折叠和聚集的分子机制。

1.2 GHz NMR的光谱分辨率和灵敏度的提高已经使研究团队更深入地研究蛋白质，并更好地了解淀粉样蛋白型蛋白质聚集的初始步骤以及tau蛋白的功能和结构，这些蛋白通常与蛋白质的功能和结构相关联，这两者都与Alzheimer’s disease.

申请

网络研讨会

推荐

2019年，布鲁克（Bruker）在田纳西州孟菲斯的圣裘德儿童研究医院（St. Jude's Children's Research Hospital）成功安装了世界上第一个1.1 GHz NMR系统。

圣裘德儿童研究医院结构生物学系主席Charalampos Kalodimos博士说：“我们很高兴收到第一个1.1 GHz NMR光谱仪，这将是我们在动态分子领域进行研究的最重要工具。分子伴侣和蛋白激酶等机器。我们赞扬布鲁克这一令人印象深刻的技术成就。”

Shortly after, in early 2020, Bruker installed the world's first 1.2 GHz NMR system at the CERM of the University of Florence. CERM is an Italian center of the European research infrastructure in structural biology.

成功装置后，佛罗伦萨大学中央大学的Lucia Banci和Claudio Luchinat教授说：“我们很高兴能够成功安装在我们的实验室中的世界上第一个1.2 GHz NMR光谱仪。我们期待将该仪器用于研究与神经退行性疾病相关的蛋白质的结构和功能，例如阿尔茨海默氏症和帕金森氏病，以及癌症和病毒蛋白结构和功能研究。目前，我们正在积极研究SARS-COV-2蛋白，我们很快将记录该冠状病毒蛋白的第一个1.2 GHz NMR光谱！”

Later in 2020, Bruker successfully installed the world’s second 1.2 GHz NMR spectrometer at Eidgenössische Technische Hochschule (ETH) Zürich in Switzerland. This 1.2 GHz spectrometer is the first one that is configured for solid-state NMR.

At the time, Professors Beat Meier, Matthias Ernst and Alexander Barnes at ETH stated: "We are very excited to have the world's first 1.2 GHz solid-state NMR spectrometer successfully installed in our lab. The system was delivered just a couple of months ago and the installation and energizing of the NMR magnet went exceptionally well. The completion of the installation marks the culmination of a project that we started with Bruker almost a decade ago. We are very much looking forward to starting our first ultra-high field solid-state NMR experiments.“

ETH utilize their 1.2 GHz NMR system to enable the development of new solid-state NMR techniques, and to apply these techniques to study materials and biological systems, including proteins fibrils which are linked to diseases such as Parkinson's and Alzheimer's. The 1.2 GHz spectrometer will also be used as a basis for further improving NMR methodology towards in-cell structural biology, and to investigate solid catalysts and functional materials, e. g. for energy conversion and data storage.

2021年初，布鲁克（BrukerMax Planck Institute (MPI)for Biophysical Chemistry in Göttingen, enabling their research teams to deliver new insights into the SARS-CoV-2 nucleocapsid (N) protein, and aiding the deeper molecular understanding of Parkinson’s and Alzheimer’s diseases.

Professor Christian Griesinger, Director and Scientific Member at the Max Planck Institute for Biophysical Chemistry in Goettingen, commented: “The new 1.2 GHz spectrometer will allow us to characterize droplets and oligomers of IDPs that are key markers in diseases such as COVID-19, neurodegenerative diseases and cancer, and which cannot be studied using crystallography or cryo-EM.”

Goettingen大学教授Markus Zweckstetter博士，德国神经退行性疾病中心的小组负责人补充说：N蛋白与病毒宿主相互作用和病毒复制生物学的关键相关性。病毒复制机器的液体样特性与N蛋白的许多本质上无序区域结合使用，这项研究非常适合GHz级NMR。”