New multi-tier workflows deliver maximum information across all facets of modern proteomics
GENEVA, Sep 06, 2011 (BUSINESS WIRE) -- Bruker, a global leader for proteomic solutions based on mass spectrometry, this week announced公关IME(TM)(公关oteomics viaIntegratedM阿尔迪和ESI), a novel and unique integrated solution for proteomics, which will be showcased at the 10th日内瓦的HUPO世界大会（http://www.hupo2011.com）。
The Proteome has turned out to be far more complex than expected at the beginning of the proteomics revolution. Complex protein dynamics in time, localization and concentration, as well as extreme structural variability due to modifications and mutations require novel, complementary and integrated approaches to generate the most useful, reliable and complete proteomics information. There is no "one size fits all“在解开proteome. Bruker's unique公关IMEsolution leads the way to integrated approaches for modern proteomics and harnesses the strengths of MALDI and ESI mass spectrometry technologies, as well as state of the art bioinformatics, without compromises. This results in enhanced protein identification, structural information, distribution and quantitative information, for data rich interpretation of the proteome.
In the innovative公关IMEsolution, bottom-up, top-down analyses as well as in-depth protein characterization merge to illuminate the true picture of the proteome, complete with biological context and confidence in data quality and extracted information. Novel approaches including glycomics, general PTM analysis and MALDI molecular imaging are fully embedded within workflows attuned to the evolving sub-fields within the overall proteomics arena.
For MALDI imaging, now emerging as an important applied proteomics tool,公关IMEprovides a complete top-down based workflow for biomarker discovery and identification from sample preparation to localization, data analysis and interpretation. Intact protein analysis for the elucidation of post-translational modifications is also fully integrated within the公关IMEsolution with the most stable and reliable second-generation Electron Transfer Dissociation (ETD) methodologies available. The core technology of公关IMEisProteinScape(TM), Bruker's market-leading proteomics database system, enabling data analysis at an unsurpassed level of efficiency for protein identification, quantitation and PTM characterization. This well accepted and constantly evolving bioinformatics suite manages and merges data from MALDI and ESI workflows and has now been further enhanced with the powerful newGlycoQuest(TM)数据库搜索聚糖结构识别。这补充了常规的肽数据库搜索工具，并在糖基质的发展场中提供了完整的糖肽识别。
Bruker的Maldi-Applications开发和蛋白质组学负责人Detlev Suckau博士评论说：“ Bruker自一开始以来一直处于基于质谱的蛋白质组学的领先地位。”“今天，我们的综合ESI和MALDI仪器一起确定了大约2500种非冗余蛋白质，在合并数据集中的细胞裂解物的自下而上分析中，FDR <1％。将这种最高性能与包括互补自上而下的完整蛋白质测量的工具相结合产生有关完整蛋白质的宝贵知识，包括序列，剪接或蛋白水解处理变体和翻译后修饰（PTMS）。”
Bruker's公关IMEsolution delivers instruments and workflows, with market-leading performance, for bottom-up, top down and PTM studies, quantitation and imaging, integrating a range of technologies including MALDI-TDS, Ion Trap ETD and high resolution UHR-ESI-QTOF, all anchored to the bioinformatics core,蛋白质景观。
The公关IMEsolution will be presented in detail in Bruker's seminar on Tuesday, September 6th, at 5 pm in room K, and in various scientific presentations at the 10thHUPO World Congress in Geneva.
About Bruker Corporation
Bruker Corporation（NASDAQ：BRKR）是用于分子和材料研究以及工业和应用分析的高性能科学工具和解决方案的领先提供商。必威东盟体育必威手机客户端有关更多信息，请访问//www.fatactor.com.
For more information regarding公关IME， 请拜访http://www.bdal.de/index.php?id=2083.
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SOURCE: Bruker
Bruker Daltonics
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