新闻发布详细信息

SEATTLE, June 25, 2018 /PRNewswire/ -- At Metabolomics 2018 (metabolomics2018.org），布鲁克今天宣布B.I.QUANT-PS™, a metabolite quantification solution on itsAvance IVDR™600 MHz NMR平台，将具有成本效益的核磁共振（NMR）筛选到高通量，转化现象研究和生物库代谢分析中。小说B.I.QUANT-PSdelivers automatic quantification of 26 disease-relevant metabolites and in the same experiment also enables lipoprotein subclass analysis. In addition, the NMR reference spectral base for pure compounds in biofluids,bbiorefcode, has been expanded to cover 800 compounds and >23.500 high quality NMR spectra.

可转让性和可重复性的B.I.QUANT-PSwas proven as part of an 11 instrument ring test in the International Phenome Center Network (IPCN). Metabolites providing information on liver, kidney and cardiovascular diseases are now accessible in a fast and fully validated analysis under DIN-ISO wet spiking.

B.I.QUANT-PS也是新的不可或缺的一部分B.I.Biobanktool™, a solution for biobanks that addresses their increasing need for standardization and quality control (QC). TheB.I.BiobanktoolQC procedure delivers information on pre-analytics, sample preparation and analytical performance. It gives information on matrix identity and integrity, e.g. for urine, EDTA-plasma, citrate plasma or serum, and it can flag sample degradation. It also confirms fasting/non-fasting, identifies contaminations, as well as reported or unreported medications. TheB.I.Biobanktoolcan generate quantitative information on 150 metabolites in urine, and >140 lipoprotein and small molecule parameters in plasma/serum. Retrospective analysis of previously recorded data is feasible.

格雷夫斯瓦尔德医科大学临床和实验室医学研究所主任马蒂亚斯·纳克（Matthias Nauck）教授评论说：“我们对在生物银行质量控制中NMR筛查的可能性感到兴奋，以提供生物元素的标准化分析数据。NMR标准将创建来自世界各地的大量数据，以支持有效的流行病学和诊断工具的开发。B.I.QUANT-PS实质上增强了生成的数据的价值，IVDRplatform can replace conventional analysis tools, which alleviates the cost pressures in clinical analysis. We just installed ourAvance IVDR在格里夫斯瓦尔大学医院，将迅速将我们的分析产品扩展到生物库，以及德国国家队列等项目。”

布鲁克还提供了新型的基于质谱的工具，用于下一代代谢组学和转化现象学研究和验证：

布鲁克刚刚宣布了革命者scimaX™ MRMS（磁共振质量光谱仪）具有超过两千万的极质量分辨率，这允许确定同位素良好结构（IFS），以确定没有液相色谱的复杂混合物中的元素公式。这scimaXis based on novel conduction-cooledMaxwell^™磁铁技术实质上是通过消除对液体冷冻剂的需求，从而使磁铁“看不见”。供电代谢4.0^®软件，scimaXnow offers a novel workflow of flow injection analysis (FIA) MRMS for large cohort, high-throughput phenomics studies, allowing analysis of ~200 samples per day.

代谢4.0also forms an integral part of ourImpact-IIultra-high resolution QTOF platform. Dr. Mathew R. Lewis, COO, MRC-NIHR National Phenome Center, Faculty of Medicine at Imperial College London, stated: "The sensitivity and precision were beyond what I expected, and robustness trials have yielded encouraging results for biofluid profiling.代谢和tasqsoftware are practical and feature-rich – well suited to the extraction and analysis of data. The total package looks like a real 'Phenomics Workhorse'."

Novel algorithms in代谢4.0now also enable the processing of 4D TIMS-separated LC-MS/MS data from Bruker's revolutionaryTimstof^™平台。这可以利用目标化合物的可重复，准确的碰撞横截面（CCS）值得出的信息，可以深入研究深色代谢组。这种唯一的CCS功能是视觉“注释质量评分”功能中的一个新参数，可置信于复合ID或已知未知数的表征。

Professor Lloyd Sumner, University of Missouri in Columbia, MO, said: "The innovative technology of ourTimstofProinstrument has enabled us to compile a library of CCS values for many plant metabolites. This additional CCS information can be searched and ultimately increases our final confidence in metabolite identifications."

了解更多，请加入我们内容丰富的午餐研讨会在6月26日星期二的代谢组学协会会议上^th，2018年。密苏里大学的嘉宾演讲嘉宾劳埃德·萨姆纳（Lloyd Sumner）博士和伦敦帝国学院的马修·刘易斯（Matthew Lewis）博士将介绍他们的最新研究。

About Bruker Corporation (NASDAQ: BRKR)
Bruker is enabling scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Bruker's high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy and nanoanalysis, and in industrial applications, as well as in cell biology, preclinical imaging, clinical phenomics and proteomics research and clinical microbiology.

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