代谢组学应用程序

代谢组学的核心是确定与疾病，药物毒性或遗传或环境变异相关的潜在小分子生物标志物。代谢组学对许多应用领域的研究方式都有很大的影响。

Validated biomarkers in clinical research or public health studies can form the basis for new diagnostic assays, and lead the way to help establish truly personalized medicine.

在药物研究中应用的代谢组学可以提供有关药物毒性的早期信息，这是药物发现中的一个核心目的。

Functional genomics studies to unravel gene functions and interactions in bacterial, plant, animal and human research benefit from metabolic profiling approaches since changes in small molecule concentrations are closely related to the observed phenotype. Metabolomics applied in Nutrition and Food revolutionized the detection of food adulteration and assists breeders in strategic trait optimization.

Also for YOUR metabolomics application Bruker offers class leading solutions to generate answers based on latest innovations for hyphenated NMR, LC-MS, GC-MS and FT-IR technologies.

In clinical research metabolomics strategies are applied in model systems such as cell cultures or animals up to large scale epidemiological studies as these approaches hold great potential to detect new biomarkers for diseases. Validated biomarkers can serve in diagnostics as well as in monitoring drug therapy - ultimately enabling real perzonalized medicine.

Validated biomarkers will also shed light on the molecular basis for diseases and point to novel drug targets, which is of primary importance in pharmaceutical research.

代谢组学在人类健康研究中的影响的一个例子是基于NMR的分析中极为有前途的项目，有助于提供对新生儿健康中天生错误的有效，可靠的筛查。它有可能生成按钮，高吞吐量筛选解决方案，同时提供非目标和靶向分析。

除NMR外，BRUKER的LC-MS和基于GC-MS的代谢组学溶液完全符合全面代谢分析，样品吞吐量，生物标志物检测，识别，验证，验证和量化的要求。

The later that a molecule or molecular class is lost from the drug development pipeline, the higher the financial cost. Minimizing attrition is therefore one of the most important aims of a pharmaceutical discovery program.

新颖的技术增加了做出正确选择的可能性早期节省资源的可能性，并促进安全，功效和盈利能力。

Metabolomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery and-development process.

药物，代谢组学，现象学，外博学和非目标筛查的目标不同。但是话虽如此，所有这些学科都有一些共同的需求，例如对感兴趣的化合物（药物代谢产物，可能的现场风格或环境暴露标记）的快速解复复制。

The integrated software solution代谢^®addresses common needs for advancing pharma, metabolomics, lipidomics, non-target screening and exposome research:

• 生物转化器的局部代谢物预测¹在代谢中启用安全的药物代谢物注释^®
• 在Metaboscape®中对多因素时间课程实验的支持支持药物代谢中代谢途径的半定量描述（BIO）制药研究的培养基分析

From raw materials to the final consumer product, the monitoring of the production and distribution cycle of food is of importance with regard to safety, authenticity and quality of food for producers, consumers and regulatory agencies. To achieve this, precise and accurate analytical tools are needed in order to ensure origin, properties, falsification, and reliability of food. The NMR based JuiceScreener is a perfect example how Bruker addressed this need with a push button solution in juice assessment applying a Targeted and Non-Targeted Multi Marker Analysis.

除食物控制外，代谢组学方法还成功地应用于食品和营养性状优化中。特别是基于代谢组学的研究，以增强营养和味觉特征，对农业产业具有巨大的潜力。Bruker的产品组合很容易启用针对性和非目标的代谢组学方法，用于基于互补LC-MS，GC-MS，NMR和FT-IR技术的全面小分子分析。

代谢组学对植物生理学研究产生了巨大影响。尽管已经研究了“古典”植物生物化学数十年，但代谢分析的整体方法在许多研究小组中找到了自己的方式。

非靶向方法可以提供有关生物或非生物因素引起的意外代谢变化以及功能基因组学研究中的基因功能的重要信息。

These non-targeted as well as targeted approaches are readily enabled by Bruker's Metabolomics solutions. In particular the combination of complementary technologies such as NMR, LC-MS and GC-MS perfectly address the need for a comprehensive analysis of small molecules.

Metabolo不可或缺的一部分mics workflow is Bruker´s tailored software to quickly pinpoint relevant information and generate knowledge.

微生物具有长期的传统作为生物活性小分子的来源 - 称为“次生代谢产物”。除了活动引导的隔离外，基于代谢组学的策略在揭示其他天然产品方面越来越成功。这些方法对从细菌和真菌菌株中发现新型的次生代谢产物有很大的希望。生物活性化合物的实例是针对靶抗病原体的新型抗生素。

Microorganisms are used in industrial scale production of biologically active small molecules, as well as other target compounds like amino acids and vitamins used e.g. for food supplementation. In order to increase the production of the desired product metabolomics is often applied to direct rational strain design based on genetic engineering. This approach often goes in hand with functional genomics studies to unravel gene functions in basic research. In summary metabolomics has become an integral part in microbial research.

布鲁克的LC-MS,GC-MS和NMR基于代谢组学溶液完全匹配了全面代谢分析，样品吞吐量，复合识别，验证和定量的要求。