Paser 2022

通过集成Paser提供的实时数据库搜索和智能获取来打破数据分析瓶颈

普遍可用

• 所有当前和未来的Timstof Pro和Flex平台都是可访问的Paser
  

4D-Proteomics™

• CCS感知数据很丰富，即使是实时数据库搜索功能也是一种现实，包括PASER，包括PTMS等PTM

Massive parallelization with GPU power

• Paser是GPU驱动的，在数千个CUDA核心上提供了巨大的计算功率

Paser数据审查

• View the intricate details of your data from the high level experimental information to a specific fragment ion spectrum of interest with confidence from the integrated viewer onboard of all PaSER boxes

• PASER很聪明，在样品采集结束时用户定义的蛋白质或肽的资格决定了样品队列的进展，这可以检查适用性，节省珍贵的样品，昂贵的消耗品和仪器时间
  

• 不再担心注入那些珍贵的样品。
  
• 不再担心浪费的乐器时间。
  
• 不再担心那些具有昂贵的试剂和样品准备的样品，只是在表现不佳的系统中注入。
  
• 不再等待QC运行以确定系统适用性。
  
• 在方法开发过程中，不再等待搜索结果。
  
  

Blazing search speed with uncompromised search results.

A）使用Paser进行实时结果的人类细胞裂解物的重复DDA运行的蛋白质ID，并针对最大值进行基准测试

b）使用PASER进行实时结果的人类细胞裂解物的重复DDA运行的肽ID，并针对最大值进行基准测试

c）抑郁剂和最大蛋白质中的97％和近90％的相同肽。

Paser提供了从实时搜索获得的一致结果，与对相同数据的离线搜索相同。由于数据库搜索算法是在GPU上运行的，因此与基于CPU的搜索相比，搜索时间可以忽略不计。

除了实时搜索外，还可以在包括PTM研究在内的特定应用程序中搜索更大的空间成为现实。

MOMA viewer powered by TIMS Viz provides the powerful ability to view 4D-Proteomics data like never seen before. The mobility separation and focusing upstream from the quadrapole and TOF results in the separation of isobaric and near isobaric species. Using other technologies and in the case of PTM enrichments and the analysis of complex samples it is common that co-eluting species that are isobaric or near isobaric in mass co-fragment. The timsTOF Pro/fleX obviates this by first separating ions by their collisional cross section. The ability to visualize, search and sort on such events has never been available before. We term isobaric masses with different mobility values mobility offset mass aligned (MOMA), and TIMS Viz can tease such events out within complex runs. TIMS Viz allows you to set tolerances to your discretion while simultaneously overlaying both features and PSMs that were observed post database search. TIMS Viz enables you to view what you never knew before.