The research field metabolomics aims at a comprehensive qualitative and quantitative analysis of all small molecules present in a cell, a tissue or even a whole organism. Responding to intrinsic or extrinsic triggers, the entirety of compounds will change. And the goal of studying these responses is to get a more holistic picture to understand e.g. the emergence and progression of diseases.
The lipidome can be considered a subset of the metabolome, covering all lipophilic compounds. Many lipids play important roles for example in cell communication and are associated with metabolic diseases. The similarity in the physical properties of lipids, despite their structural diversity demands for dedicated workflow solutions. These are different compared to classical metabolomics approaches. Both applications are supported in MetaboScape and both are facilitated by the additional dimension that is achieved using Trapped Ion Mobility Spectrometry (TIMS).
This poster hall shows a unique collection of investigations that leverage Bruker technology, e.g. showing the benefit of CCS values and the PASEF acquisition mode. We are very thankful to everybody who contributed their research results.
And we hope you enjoy reading through this poster hall as much as we enjoyed putting it together.
Poster 2021:CCS预测Pro
Poster 2021:MetaboScape 2022 for core labs
Poster 2020:4-dimensional annotation of Metabolomics features: CCS values as an additional source for higher confidence
Poster 2020:未靶向的UHLC-HR-QTOF-MS代谢组学研究对代谢产物的代谢产物与阿斯彭树中的木材形成对照
Poster 2020:Integrating MetaboScape and PollyTM for the analysis of LC-TIMS-MS and LC-MS based fluxomics
Poster 2020:Inlet Probe Coupled to Trapped Ion Mobility Time-of-Flight Mass Spectrometry
海报2019:将LC-TIMS-MS/MS数据的4D峰采摘纳入基于GNP的分子网络,用于代谢组学和脂肪组学分析
海报2019:使用强大的硬件和信号校正的大型队列和临床代谢组学研究的质量控制和质量控制的集成工作流程
海报2019:Enabling Rapid and High-confidence Metabolite Identification using HILIC-QTOF based MS/MS-RT library
海报2019:用于研究生物样品的代谢组和脂肪组工作流的整合
Poster 2020:Metabolite identification by assignment of collisional-cross section (CCS) and isotopic fine structure (IFS)
Poster 2020:KLK8缺乏小鼠使用不同仪器的代谢组学研究电离/检测方法
Poster 2020:Untargeted FTICR-MS based Plasma Metabolomic Analysis and Translation to Type 2 Diabetes
海报2019:磁共振质谱分析的粘液细菌提取物 - 更高的分辨率,更深的见解?
海报2019:An Integrated Ultra-High Resolution FTICR-MS Based Platform for Metabolomics
For Research Use Only. Not for use in clinical diagnostic procedures.