SKYSCAN 1276 CMOS EDITION
高分辨率
在台式机中
Lo más destacado
强调
The SKYSCAN 1276 CMOS Edition is a high performance, stand-alone, fast, desktop in vivo microCT with continuously variable magnification for scanning small laboratory animals (mice, rats, ...) and biological samples. An optional Large Animal Transport System (LATS) is available which enables the system to mount also large animals including rabbits.
Skyscan 1276 CMOS版具有高分辨率，大图像大小，圆形和螺旋（螺旋）扫描和重建以及低剂量成像的无与伦比的组合。图像视野宽达75毫米，长310毫米，可以进行全身鼠标和大鼠扫描。可变放大倍数允许扫描骨和组织样品，其空间分辨率高至2.8 µm像素大小。可变的X射线能量与一系列过滤器相结合，可确保从肺组织到具有金属植入物的骨骼的各种研究应用的最佳图像质量。该系统可以通过连续的龙门旋转进行扫描，并在扫描周期降低到3.9秒的情况下进行扫描模式。此外，体内Microct中的Skyscan 1276 CMOS对动物的低辐射剂量允许在纵向临床前研究中进行多次扫描，而没有不需要辐射诱导的副作用的风险。完全集成的生理监测软件包允许始终通过视频流，ECG，温度和呼吸检测来监视和控制动物的健康。
The SKYSCAN 1276 CMOS is complemented by 3D.SUITE. This extensive software suite covers GPU-accelerated reconstruction, 2D/ 3D morphological analysis, as well as surface and volume rendering visualization.
Características
特征s
Mouse and Rat Cassettes
The SKYSCAN 1276 CMOS system is supplied with exchangeable animal cassettes that can be used in all Bruker in-vivo imaging instruments such as MRI, micro-PET, micro-SPECT, bio-luminescence, biofluorescence, etc. to collect multimodal information. It allows co-registration of functional and morphological information from the same animal.
触摸屏控件
Skyscan 1276 CMOS系统的用户界面简单明了。该仪器可以通过计算机屏幕以及嵌入式力敏感触摸屏进行控制，该屏幕可以通过手套的手操作。触摸屏允许选择扫描协议，调整动物床位的位置以及对成像和扫描的控制。如果从触摸屏启动了多次扫描，则该软件将自动保存获得的数据，以分离具有增量分配的文件夹名称和数据集文件前缀的子文件夹。
ON-SCREEN REAL-TIME DOSE METER
Skyscan1276控制软件包括实时屏幕剂量表。它表明扫描过程中动物体吸收的剂量的估计。该测量基于从用电子剂量计测量的动物的X射线投影图像计算出的吸收。剂量表显示累积的剂量或剂量率。它经过校准，可在标准小鼠和大鼠盒中吸收X射线。这样，它可以测量扫描过程中动物体本身吸收的X射线剂量。扫描记录文件中记录了动物在扫描过程中吸收的剂量以及所有扫描和重建设置。
Integrated physiological monitoring
The physiological monitoring system includes video monitoring of an animal with real-time movement detection, ECG and breathing detection, and temperature stabilization. A 5 megapixel color camera is mounted above the animal bed along with white LED illumination to introduce a real-time image of the animal during the scan. The software analyses the video stream from a user-selected area of the image where breathing movement is visible. These movements are converted into a movement waveform to provide breathing time marks for time-resolved reconstructions. The face mask on the animal bed is connected to an air/gas flow sensor for direct breathing detection. The ECG electrodes in the animal cassette are connected to a sensitive ECG amplifier. Both breathing and ECG signals are digitized and displayed as real-time profiles on-screen. The monitoring also includes temperature stabilization by heated airflow, which maintains the scanned animal at a selected temperature, to prevent cooling of the animal under anaesthesia.
Aplicaciones
Highlighted Applications
Mineralized Tissues
布鲁克’s third generation SKYSCAN 1276 CMOS is – it’s fair to say – the leadingin vivomicroCT bone solution, proving its worth in hundreds of research animal facilities worldwide. No other system has an x-ray camera optically tailored precisely for that impossible combination – high resolution with low dose, for the rodent bone. The full range of rodent and small animal bone disease models can be assessed and quantified reliably for study after study.
- Physiological monitoring is design-central in SKYSCANin vivoscanners, not an add-on. High quality video, breathing monitoring by video-movement and pressure, ECG and thermostat-controlled warming, put the animal’s welfare at center stage.
- A large carbon fiber bed for rats and a steel tray for rabbits, for orthopedic implantation studies. Optimal hindlimb positioning for bone scans in mouse, rat and rabbit.
- 具有全面3D和2D参数的骨形态计（ASBMR命名法），其光密度计，包括直径2-32mm的BMD校准参考。
- Advanced functions include 3D registration for longitudinalin vivo研究，自适应阈值，Euler连接性，分形，各向异性和立体学，过滤，布尔逻辑运算符等。
Pneumology
Skyscan 1276 CMOS是一种灵活的高性能肺成像解决方案。在短扫描时间内获得急剧的肺部图像，并具有安全的电离辐射水平。在同一扫描仪中ex vivosample scanning capability at a voxel size down to 2.8 micron true resolution allowing imaging lung tissue at the alveolar level of architecture for advanced lung disease characterization.
- Physiological monitoring is design-central in SKYSCANin vivoscanners, not an add-on. High quality video, breathing monitoring by video-movement and pressure, ECG and thermostat-controlled warming, support in vivo lung studies with minimized welfare impact on the animal.
- 先进的全physi动物磁带连接ological monitoring and anesthesia yet detachable with a single locking button – the universal Brukerin vivobed. Support for third party devices such as ventilators (e.g. Scireq FlexiventTM）。
- Comprehensive time-gating solutions: prospective and retrospective, time and image based intrinsic gating. Continuous rotation available for fast low-dose gated scanning.
- Full in-house software solution for lung function analysis in 4D: tidal volume, lung volume and HU density for pathology assessment, lung tumour morphometric segmentation, 3D registration of sequential scans to map disease progression, auto-separation of lung from other animal tissues in CT-Analyser software.
心血管应用
啮齿动物的心脏时间门控4D成像是体内Microct成像的技术基准，而Bruker的Skyscan 1276 CMOS遇到了这一挑战。在短扫描时间内提供急剧分辨的心脏肺单图像或双门控图像，并具有安全的电离辐射水平 - 可靠地研究。
- 生理监测是在体内扫描仪中设计中心的，而不是附加组件。高质量的视频，视频移动和压力的呼吸监测，心电图和恒温器控制的变暖，在体内心肺研究中支持对动物的福利影响最小
- 先进的全physi动物磁带连接ological monitoring and anesthesia provision yet detachable with a single locking button – the universal Bruker in vivo bed. Support for third party devices such as ventilators (e.g. Scireq FlexiventTM）。
- Comprehensive time-gating solutions: prospective and retrospective, time and image based intrinsic gating. Continuous rotation available for fast low-dose gated scanning.
- Full in-house software solution for cardiac function analysis in 4D: ejection volume, other cardiac chambers and aorta, time-analysis of cardiac wave-train including regularity and fractality, with flexible segmentation and analysis of the cardiac cycle in CT-Analyser software.
Application Gallery
体积渲染的股骨的3D模型具有小梁厚度的颜色编码表示，以2.8μm像素尺寸扫描。
3D model of a rat skull, scanned at 20µm voxel sizein vivo.
体积渲染的小鼠膝盖的3D模型，以6 µm的体素尺寸扫描in vivo.
3D representation of the mouse vasculature, scannedin vivoat 7 µm voxel size after a bolus injection of vascular contrast agent.
通过小鼠肺扫描的正交横截面in vivo, showing the blood vessels and large airways inside the lung.
Cross-sectional slices through a mouse body, scanned at 17 µm voxel sizein vivowithout contrast agent injection.
Cross-section through a mouse lung, scannedex vivo在3 µm体素大小的化学干燥后。
Orthogonal slices through a mouse femur, scanned at 2.8 µm voxel size.
通过鼠标的正交切片，扫描in vivo对比度注射后。
3D model of a mouse lung, made transparent to visualize the lung tumour tissue in green.
Especificaciones
Specifications
SKYSCAN 1276 CMOS Specifications
特征 |
Specification |
Benefit |
X-ray source |
40 - 100 kV，20W <5 µm斑点大小在4 W Automated 6-position filter changer |
无维护的密封高分辨率X射线源 |
X-ray detector |
16 MP SCMOS探测器（4096 x 4096像素） |
Fine-pitched detectors for achieving highest resolution |
Spatial resolution |
2.8µmsmallest pixel size 6µm spatial resolution (10% MTF) |
体内成像的最高真实分辨率 |
| Object size | 75 mm diameter 310 mm height |
Capable to scan a large range of sample sizes |
Dimensions |
with ATS: 954mm W x 940mm H x 1190mm L (1560mm L with open specimen chamber), 330kg 带有纬度：954mm W x 940mm h x 1340mm l (1740mm L with open specimen chamber), 450kg |
Space-saving desktop system that fits in every lab |
电源 |
100-240V AC, 50-60Hz, 3A max. |
Minimum installation requirements, a standard power supply suffices |
Software
POSITION, SCAN, RECONSTRUCT and ANALYZE
包括所有的软件需要t力量XRM解决方案o collect and analyze data. An intuitive graphical user interface with user guided parameter optimization support both expert and novice users. By using the latest GPU powered algorithms, reconstruction time is substantially reduced. CTVOX, CTAN and CTVOL combine to form a powerful suite of software for both qualitative and quantitative analysis of models.
Measurement Software:
SKYSCAN 1272 – Instrument control, measurement planning and collection
Reconstruction Software:
NRECON – Transforms the 2D projection images into 3D volumes
Analysis Software:
Dataviewer– Slice-by-slice inspection of 3D volumes and 2D/3D image registration
CTVOX– Realistic visualization by volume rendering
ctan– 2D/3D image analysis & processing
CTVOL– Visualization of surface models to export for CAD or 3D printing
Noticias y eventos
News & Events
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Soporte
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