SkyScan 1276

Skyscan 1276是一种高性能，独立的，快速的，台式机，体内微观，用于扫描小型实验室动物（小鼠，大鼠，...）和生物样品，具有不断变化的放大倍率。有可选的大型动物运输系统（LATS），使该系统还可以安装包括兔子在内的大型动物。

Skyscan 1276具有高分辨率，大图像大小，圆形和螺旋（螺旋）扫描和重建以及低剂量成像的无与伦比的组合。图像视野宽度高达80毫米，长300毫米，可以进行全身鼠标和大鼠扫描。可变放大倍数允许扫描骨和组织样品，其空间分辨率高至2.8 µm像素大小。可变的X射线能量与一系列过滤器相结合，可确保从肺组织到具有金属植入物的骨骼的各种研究应用的最佳图像质量。该系统可以通过连续的龙门旋转进行扫描，并在扫描周期降低到3.9秒的情况下进行扫描模式。此外，Skyscan 1276体内微分组对动物的低辐射剂量允许在纵向临床前研究中进行多次扫描，而没有不必要的辐射引起的副作用的风险。完全集成的生理监测软件包允许始终通过视频流，ECG，温度和呼吸检测来监视和控制动物的健康。

The SKYSCAN 1276 is complemented by 3D.SUITE. This extensive software suite covers GPU-accelerated reconstruction, 2D/ 3D morphological analysis, as well as surface and volume rendering visualization.

The SkyScan 1276 system is supplied with exchangeable animal cassettes that can be used in all Bruker in-vivo imaging instruments such as MRI, micro-PET, micro-SPECT, bio-luminescence, biofluorescence, etc. to collect multimodal information. It allows co-registration of functional and morphological information from the same animal.

Skyscan 1276系统的用户界面简单明了。该仪器可以通过计算机屏幕以及嵌入式力敏感触摸屏进行控制，该屏幕可以通过手套的手操作。触摸屏允许选择扫描协议，调整动物床位的位置以及对成像和扫描的控制。如果从触摸屏启动了多次扫描，则该软件将自动保存获得的数据，以分离具有增量分配的文件夹名称和数据集文件前缀的子文件夹。

Skyscan1276控制软件包括实时屏幕剂量表。它表明扫描过程中动物体吸收的剂量的估计。该测量基于从用电子剂量计测量的动物的X射线投影图像计算出的吸收。剂量表显示累积的剂量或剂量率。它经过校准，可在标准小鼠和大鼠盒中吸收X射线。这样，它可以测量扫描过程中动物体本身吸收的X射线剂量。扫描记录文件中记录了动物在扫描过程中吸收的剂量以及所有扫描和重建设置。

生理监测系统包括视频monitoring of an animal with real-time movement detection, ECG and breathing detection, and temperature stabilization. A 5 megapixel color camera is mounted above the animal bed along with white LED illumination to introduce a real-time image of the animal during the scan. The software analyses the video stream from a user-selected area of the image where breathing movement is visible. These movements are converted into a movement waveform to provide breathing time marks for time-resolved reconstructions. The face mask on the animal bed is connected to an air/gas flow sensor for direct breathing detection. The ECG electrodes in the animal cassette are connected to a sensitive ECG amplifier. Both breathing and ECG signals are digitized and displayed as real-time profiles on-screen. The monitoring also includes temperature stabilization by heated airflow, which maintains the scanned animal at a selected temperature, to prevent cooling of the animal under anaesthesia.