Toxtyper^®

Toxtyper^®基于市场上最快的LC-MSN技术，Amazon Speed提供了强大而自动化的药物测试解决方案。Toxtyper^®provides a combination of high-performance LC-MS/MS and confident identification with full transferability of library search results from lab to lab.

Toxtyper^®开发解决方案以满足法医和临床研究实验室的需求。独特的专利SmartFrag技术实际上消除了任何变化，因此需要从MS/MS进程进行调整。

The intuitive, easy-to-use Toxtyper^®user interface is designed specifically for non-MS experts. Its push-button sample analysis is ideal for a multi-user environment and 24/7 operation.

Key attributes of the Toxtyper^®:

• Tune-free, ready for use, robust LC-MSn solution for 24/7 toxicology screening
• 易于使用的软件，专为非MS专家使用而设计
• 全面和自信的筛选结果,based on high quality curated spectral libraries
• Less than 12 minutes from injection to report, fast polarity switching for detection of basic, acidic and neutral compounds in one run
• Allows for streamlined sample preparation – in particular for urine – without need for hydrolysis and/or derivatization
• 开放库概念启用简单快速的库更新，例如用于药物筛查应用中的新精神活性物质（NP）
• 提供半定量结果
  
  

Toxtyper^®拥有一个精心策划的高质量光谱文库，其中大约3000个MSN光谱具有近1200种研究毒理学兴趣。它还为滥用药物（DOA）筛查研究提供了较小的目标图书馆。Toxtyper^®supports the Maurer/Wissenbach/Weber LC-MSn library* containing almost 6000 drugs and metabolites.

*Maurer/Wissenbach/Weber LC-MSN毒品图书馆，毒药及其代谢物第二版；ISBN：978-3-527-34649

开放库概念
新的精神活性物质（NP）（例如合成大麻素）的药物滥用最近增加，不断改变其分析要求，这意味着必须迅速适应筛查方法。

Toxtyper^®libraries are constantly updated with contributions from customers and collaboration partners. User-defined library entries can be created quickly and easily, allowing laboratories to respond rapidly to new patterns of drug abuse.

为非MS专家设计的易于使用的软件
Toxtyper^®软件可以使用色谱图和MSN光谱视图对库搜索结果进行一单击审查，以评估快速交互式结果。

可以通过各种参数对识别化合物进行排序，包括信号强度，保留时间或字母顺序排列。颜色编码有助于审核过程。

Toxtyper^®: a complete solution for clinical research and forensic toxicology
当今的法医毒理学和临床研究实验室受到对快速准确结果的需求以及实验室效率和降低成本的挑战。新药不断出现进入市场，需要经常更新样品筛选方法。

Toxtyper^®LC-MSn approach with library searching is an easy-to-use, flexible, and reliable screening solution for modern toxicology research.

Reproducibility and transferability through SmartFrag
Data-dependent MSn acquisition using Bruker’s patented SmartFrag technology enables the successful analysis of different types of compounds, regardless of their chemical nature, concentration, or sample matrix. The resulting MSn spectra and identification results are completely reproducible and transferable from instrument to instrument and lab to lab.

From comprehensive screening to semi-quantification:

样品制备
可以在Toxtyper中使用不同公认的样品制备方法，例如液态液体提取（LLE），固相提取（SPE）或简单的蛋白质沉淀^®workflow. Protein precipitation is quick and easy and is well suited to the comprehensive analysis of a wide range of analytes.

One example is to demonstrate the simultaneous, highly sensitive detection of drugs in human urine. Following simple sample preparation (liquid-liquid-extraction) of 1 mL of urine, the Toxtyper^®允许检测到0.8 ng/ml。

Tailor-made sub-libraries for increased sensitivity
Toxtyper^®提供了为特定需求生成较小库的选项。

Screening, confirmation, and semi-quantitation in one run
为了增加全面筛选的价值，标准的toxtyper^®使用Toxtyper分析^®and DOA libraries can be extended by semi-quantification.

After performing a one-point calibration for the target compounds using two or more internal standards, the subsequent Toxtyper^®分析提供定性筛选结果和半定量值，例如集中度以上或低于目标值。

Although drug analysis using immunological methods is fast, it is not always reliable. The available screening tests can easily lead to false positive results. For the confirmation of such immunoassay results, complex and time-consuming GC-MS analysis has been so far performed by the Stuttgart hospital.

Since March 2017, the Toxtyper^®系统已用于筛查血液，口服液体和尿液中的药物和毒素。没有耗时的样品准备，毒剂^®提供高度具体且可重现的快速可靠结果。另外，毒剂^®在神经学诊断不可逆的脑衰竭之前，在毒理学分析中提供了高度的安全性。

Case Study
一名34岁的头晕，恶心和呕吐的患者被送往急诊室。解剖学表明药物消耗，但患者否认使用非法药物。使用各种免疫测定的尿液筛查对苯丙胺，巴比妥酸盐，苯二甲培素，可卡因，鸦片和大麻均为阴性。Toxtyper^®identified Mitragynin and several metabolites of Paynanthein and Speciociliantin, which are alkaloids present in leaves and fruits of the Kratom tree. Kratom is used for substitution of Opioids and is not regulated by German narcotics law.