timsTOF

timsTOF

The timsTOF represents the next generation of ion mobility mass spectrometers

Adding the 4th dimension

Increases depth of LC-MS/MS workflows

Timstof-Portrait

Highlights

timsTOF

Highlights

Resolution
Consistently high ion mobility resolution unravels the complexity of samples and unlocks insights that remain hidden in standard mass spectrometry.
Flexibility
基于TIMS的可调节离子移动性分离允许以各种有意义的方式探索样品。
Confidence
Boosts confidence and specificity of compound identification with an expanded set of orthogonal qualifiers that are measured with great accuracy.

特征

timsTOF

Next generation ion mobility separation

  • 您的分析是否对某些化合物(例如结构性异构体)视而不见?
  • Does trying to resolve overlapping fragment ion spectra give you a headache?
  • Is your mass spectrometer as flexible as you need for everyday challenges in the lab?

离子迁移率是对质谱的强大扩展,可提供有关离子三维结构的信息,并增加了对复合表征的峰值容量和置信度。

timsTOF was engineered by Bruker experts as an open platform to accelerate the adoption of ion mobility-mass spectrometry analysis across research applications.

高度独特的TIMS设计实现了无与伦比的占空比(高达100%),IMS分辨率(R> 200)的显着改善,前所未有的碰撞横截面(CCS)可重复性和高灵敏度。

Benefits

timsTOF

Flexibility to empower your ideas

With the flip of a switch, augment the peak capacity of your analytical system beyond chromatography and time-of-flight separation. No penalty in analysis time, no penalty in sensitivity.

timsTOF features adjustable ion mobility separation based on Trapped Ion Mobility Spectrometry (TIMS), so you can explore samples in various and meaningful ways. Furthermore, timsTOF uses an open data format (*.tdf) that introduces full transparency, efficiency and flexibility into your data analysis strategy.

timsTOF

解决方案 - 更多控制,更多答案

timsTOF combines high ion mobility resolution with ultra-high resolution QTOF technology for optimal performance. imeXTM technology further boosts the functionality by making ion mobility resolution an adjustable parameter.

Investigate your sample in imeX survey mode for mobility-resolved full scans, and then extend your workflow with a detailed examination of selected compounds and precise collisional cross sections (CCS). Increase ion mobility resolution up to 200 for unique insights into your samples in imeX ultra mode.

timsTOF

Confidence - Expand what you know about a compound

自信是基于识别化合物orthogonal qualifiers that are reliably reported with high accuracy. With timsTOF, exact mass measurements (low ppm) are complemented with Bruker’s unique isotopic pattern fidelity (True Isotopic Pattern or TIPTM) and precise collisional cross section determination (<0.5% RSD).

Instrument geometry and the positioning of ion mobility separation prior to quadrupole isolation and fragmentation generate clear fragmentation spectra to further enhance certainty of identifications.

申请

timsTOF

分子的深层表征多种研究应用

Analyze isomeric compounds
Ion mobility separation is a very powerful approach to separate isobaric or isomeric compounds. Especially in combination with high resolution accurate mass spectrometry, ion mobility separation greatly enhances substance identification and characterization capabilities, and provides an additional physical property of compounds, the CCS values.

高信心法医筛查
离子迁移率结合高分辨率(HRES)质谱法可以识别和表征已知的以及未知的设计师药物分析物及其代谢物。

表征植物代谢产物和次生代谢产物

网络研讨会

Testimonials

“我们已经在实验室中使用了离子移动性,但是Timstof现在提供的离子移动性分辨率更高,基于这项技术的不同应用程序有很大的空间。”

Prof. Carlos Afonso, Professor of Chemistry, Université de Rouen-Normandie, France

Consumables

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