高分辨率
in a desktop
The SKYSCAN 1276 CMOS Edition is a high performance, stand-alone, fast, desktop in vivo microCT with continuously variable magnification for scanning small laboratory animals (mice, rats, ...) and biological samples. An optional Large Animal Transport System (LATS) is available which enables the system to mount also large animals including rabbits.
The SKYSCAN 1276 CMOS Edition has an unrivalled combination of high resolution, big image size, round and spiral (helical) scanning and reconstruction, and low dose imaging. The image field of view up to 75 mm wide and 310 mm long allows full body mouse and rat scanning. The variable magnification allows scanning bone and tissue samples with high spatial resolution down to 2.8 µm pixel size. Variable X-Ray energy combined with a range of filters ensures optimal image quality for diverse research applications from lung tissue to bone with metal implants. The system can perform scanning with continuous gantry rotation and in step-and-shoot mode with scanning cycles down to 3.9 sec. Furthermore, the SKYSCAN 1276 CMOS in vivo microCT administers a low radiation dose to the animals allowing multiple scans in longitudinal preclinical studies without the risk of unwanted radiation-induced side effects. The fully integrated physiological monitoring package allows monitoring and controlling the animal's wellbeing at all times through a video stream, ECG, temperature and breathing detection.
The SKYSCAN 1276 CMOS is complemented by 3D.SUITE. This extensive software suite covers GPU-accelerated reconstruction, 2D/ 3D morphological analysis, as well as surface and volume rendering visualization.
The SKYSCAN 1276 CMOS system is supplied with exchangeable animal cassettes that can be used in all Bruker in-vivo imaging instruments such as MRI, micro-PET, micro-SPECT, bio-luminescence, biofluorescence, etc. to collect multimodal information. It allows co-registration of functional and morphological information from the same animal.
The user interface of the SKYSCAN 1276 CMOS system is simple and intuitive. The instrument can be controlled from the computer screen and also from the embedded force-sensitive touchscreen, which can be operated by gloved hands. The touchscreen allows selection of scanning protocol, adjusting the animal bed position and control of imaging and scanning. Where multiple scans are started from the touchscreen, the software will automatically save acquired data to separate subfolders with incrementally assigned folder names and dataset file prefixes.
The SkyScan1276 control software includes a real-time on-screen dose meter. It indicates an estimation of the dose absorbed by the animal body during scanning. The measurement is based on the absorption calculated from X-ray projection images of the animal cross-calibrated with electronic dosimeter measurements. The dose meter shows accumulated dose or dose rate. It is calibrated for X-ray absorption in the standard mouse and rat cassettes. In this way it measures the X-ray dose absorbed in animal body itself during scanning. The dose absorbed by the animal during a scan is documented in the scan log-file together with all scan and reconstruction settings.
The physiological monitoring system includes video monitoring of an animal with real-time movement detection, ECG and breathing detection, and temperature stabilization. A 5 megapixel color camera is mounted above the animal bed along with white LED illumination to introduce a real-time image of the animal during the scan. The software analyses the video stream from a user-selected area of the image where breathing movement is visible. These movements are converted into a movement waveform to provide breathing time marks for time-resolved reconstructions. The face mask on the animal bed is connected to an air/gas flow sensor for direct breathing detection. The ECG electrodes in the animal cassette are connected to a sensitive ECG amplifier. Both breathing and ECG signals are digitized and displayed as real-time profiles on-screen. The monitoring also includes temperature stabilization by heated airflow, which maintains the scanned animal at a selected temperature, to prevent cooling of the animal under anaesthesia.
Bruker’s third generation SKYSCAN 1276 CMOS is – it’s fair to say – the leading体内Microct骨骼解决方案,证明了其在全球数百个研究动物设施中的价值。没有其他系统具有X射线摄像机的光学量身定制,可精确地定制这种不可能的组合 - 对于啮齿动物骨,高剂量的高分辨率。可以在研究后可靠地评估和量化各种啮齿动物和小动物骨病模型。
1276年SKYSCAN CMOS flexible high-performance lung imaging solution. Sharply time-gated lung images are obtained in short scan times with safe levels of ionizing radiation. In the same scanner there isex vivo体素尺寸的样品扫描能力降低到2.8微米真实分辨率,允许在建筑的肺泡水平上进行成像,以进行晚期肺部疾病的表征。
Cardiac time-gated 4D imaging of the rodent is the technical benchmark of microCT imaging in vivo and Bruker’s SKYSCAN 1276 CMOS meets this challenge. Sharply time-resolved cardiac-lung single or dual-gated images are provided in short scan times with safe levels of ionizing radiation – reliably for study after study.
Volume rendered 3D model of a femur with color-coded representation of the trabecular thickness, scanned at 2.8 μm pixel size.
大鼠头骨的3D模型,以20µm的体素尺寸扫描体内。
Volume rendered 3D model of a mouse knee, scanned at 6 µm voxel size体内。
扫描小鼠脉管系统的3D表示体内注射血管造影剂后,在7 µm的体素大小处。
Orthogonal cross-sections through the mouse lung scanned体内, showing the blood vessels and large airways inside the lung.
Cross-sectional slices through a mouse body, scanned at 17 µm voxel size体内没有对比剂注射。
Cross-section through a mouse lung, scannedex vivoafter chemical drying at 3 µm voxel size.
Orthogonal slices through a mouse femur, scanned at 2.8 µm voxel size.
Orthogonal slices through a mouse heart, scanned体内after contrast agent injection.
3D model of a mouse lung, made transparent to visualize the lung tumour tissue in green.
Feature |
Specification |
Benefit |
X射线源 |
40 – 100 kV, 20W < 5 µm spot size at 4 W Automated 6-position filter changer |
Maintenance-free sealed high resolution X-ray source |
X-ray detector |
16 Mp sCMOS detector (4096 x 4096 pixels) |
实现最高分辨率的精细探测器 |
Spatial resolution |
2.8µmsmallest pixel size 6µm spatial resolution (10% MTF) |
Highest true resolution for in vivo imaging |
对象大小 | 75 mm diameter 310 mm height |
Capable to scan a large range of sample sizes |
Dimensions |
带有ATS:954mm W x 940mm H x 1190mm L (1560mm L带开放式标本室),330 kg with LATS: 954mm W x 940mm H x 1340mm L (1740mm L带开放式标本室),450kg |
Space-saving desktop system that fits in every lab |
Power supply |
100-240V AC, 50-60Hz, 3A max. |
Minimum installation requirements, a standard power supply suffices |
Bruker XRM解决方案包括收集和分析数据所需的所有软件。具有用户指导参数优化的直观图形用户界面支持专家和新手用户。通过使用最新的GPU动力算法,重建时间大大减少了。CTVOX,CTAN和CTVOL结合在一起,形成了一个强大的软件套件,用于模型的定性和定量分析。
Measurement Software:
Skyscan 1276 CMOS版本– Instrument control, measurement planning and collection
Reconstruction Software:
NRECON - 将2D投影图像转换为3D卷
分析软件:
DATAVIEWER– Slice-by-slice inspection of 3D volumes and 2D/3D image registration
CTVOX- 通过音量渲染的现实可视化
CTAN– 2D/3D image analysis & processing
CTVOL- 可视化表面模型以导出CAD或3D打印
Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.
LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory