SKYSCAN 1276 CMOS EDITION
高分辨率
in a desktop
하이라이트
Highlights
Skyscan 1276 CMOS版是高性能，独立的，快速的，台式机，体内微型ct，用于扫描小型实验室动物（小鼠，老鼠，...）和生物样品的不断变化放大倍率。有可选的大型动物运输系统（LATS），使该系统还可以安装包括兔子在内的大型动物。
1276年SKYSCAN互补金属氧化物半导体Edition has an unrivalled combination of high resolution, big image size, round and spiral (helical) scanning and reconstruction, and low dose imaging. The image field of view up to 75 mm wide and 310 mm long allows full body mouse and rat scanning. The variable magnification allows scanning bone and tissue samples with high spatial resolution down to 2.8 µm pixel size. Variable X-Ray energy combined with a range of filters ensures optimal image quality for diverse research applications from lung tissue to bone with metal implants. The system can perform scanning with continuous gantry rotation and in step-and-shoot mode with scanning cycles down to 3.9 sec. Furthermore, the SKYSCAN 1276 CMOS in vivo microCT administers a low radiation dose to the animals allowing multiple scans in longitudinal preclinical studies without the risk of unwanted radiation-induced side effects. The fully integrated physiological monitoring package allows monitoring and controlling the animal's wellbeing at all times through a video stream, ECG, temperature and breathing detection.
Skyscan 1276 CMOS由3D.Suite补充。这个广泛的软件套件涵盖了GPU加速重建，2D/ 3D形态学分析以及表面和体积渲染可视化。
특징
Features
鼠标和大鼠盒
Skyscan 1276 CMOS系统提供可交换的动物盒，可用于所有Bruker内部体内成像仪器，例如MRI，MIRI-PET，MICRO-SPECT，MICRO-SPECT，BIO-LOUMENECTIC，BIO荧光，生物荧光等，以收集多模式信息。它允许从同一动物共同注册功能和形态信息。
Touchscreen Control
The user interface of the SKYSCAN 1276 CMOS system is simple and intuitive. The instrument can be controlled from the computer screen and also from the embedded force-sensitive touchscreen, which can be operated by gloved hands. The touchscreen allows selection of scanning protocol, adjusting the animal bed position and control of imaging and scanning. Where multiple scans are started from the touchscreen, the software will automatically save acquired data to separate subfolders with incrementally assigned folder names and dataset file prefixes.
ON-SCREEN REAL-TIME DOSE METER
The SkyScan1276 control software includes a real-time on-screen dose meter. It indicates an estimation of the dose absorbed by the animal body during scanning. The measurement is based on the absorption calculated from X-ray projection images of the animal cross-calibrated with electronic dosimeter measurements. The dose meter shows accumulated dose or dose rate. It is calibrated for X-ray absorption in the standard mouse and rat cassettes. In this way it measures the X-ray dose absorbed in animal body itself during scanning. The dose absorbed by the animal during a scan is documented in the scan log-file together with all scan and reconstruction settings.
综合生理监测
生理监测系统包括对动物进行实时运动检测，心电图和呼吸检测以及温度稳定的视频监测。一个5百万像素的颜色摄像头安装在动物床上方以及白色LED照明上，以在扫描过程中引入动物的实时图像。该软件从图像的用户选择区域分析了视频流，其中可见呼吸运动。这些运动被转换为运动波形，为时间分辨的重建提供呼吸时间标记。动物床上的面膜连接到空气/气流传感器以直接呼吸检测。动物盒中的ECG电极连接到敏感的ECG放大器。呼吸和心电图信号都在屏幕上进行数字化并显示为实时轮廓。监测还包括加热气流的温度稳定，该气流将扫描动物保持在选定的温度下，以防止在麻醉下冷却动物。
응용
Highlighted Applications
Mineralized Tissues
布鲁克（Bruker）的第三代摩西班1276 CMO是 - 可以说是领先的in vivomicroCT bone solution, proving its worth in hundreds of research animal facilities worldwide. No other system has an x-ray camera optically tailored precisely for that impossible combination – high resolution with low dose, for the rodent bone. The full range of rodent and small animal bone disease models can be assessed and quantified reliably for study after study.
- 生理监测是摩西班的设计中心in vivoscanners, not an add-on. High quality video, breathing monitoring by video-movement and pressure, ECG and thermostat-controlled warming, put the animal’s welfare at center stage.
- A large carbon fiber bed for rats and a steel tray for rabbits, for orthopedic implantation studies. Optimal hindlimb positioning for bone scans in mouse, rat and rabbit.
- Bone morphometry (ASBMR nomenclature) with comprehensive 3D and 2D parameters, with densitometry including BMD calibration references over a 2-32mm diameter size range.
- 高级功能包括纵向的3D注册in vivostudies, adaptive thresholding, Euler connectivity, fractal, anisotropy and stereology, filtering, Boolean logical operators and much more.
肺科
1276年SKYSCAN互补金属氧化物半导体is a flexible high-performance lung imaging solution. Sharply time-gated lung images are obtained in short scan times with safe levels of ionizing radiation. In the same scanner there is离体sample scanning capability at a voxel size down to 2.8 micron true resolution allowing imaging lung tissue at the alveolar level of architecture for advanced lung disease characterization.
- 生理监测是摩西班的设计中心in vivoscanners, not an add-on. High quality video, breathing monitoring by video-movement and pressure, ECG and thermostat-controlled warming, support in vivo lung studies with minimized welfare impact on the animal.
- Advanced animal cassettes connected for full physiological monitoring and anesthesia yet detachable with a single locking button – the universal Brukerin vivo床。支持第三方设备，例如呼吸机（例如Scireq FlexiventTM值).
- 全面的时间门控解决方案：前瞻性和回顾性，基于时间和图像的内在门控。连续旋转可用于快速低剂量门控扫描。
- 用于4D的肺功能分析的完整内部软件解决方案：潮汐体积，肺部体积和HU密度用于病理评估，肺肿瘤形态计量分段，对绘制疾病进展的顺序扫描的3D注册，与其他动物组织自动分离疾病进展，在其他动物组织中自动分开CT-Analyser软件。
Cardiovascular Applications
Cardiac time-gated 4D imaging of the rodent is the technical benchmark of microCT imaging in vivo and Bruker’s SKYSCAN 1276 CMOS meets this challenge. Sharply time-resolved cardiac-lung single or dual-gated images are provided in short scan times with safe levels of ionizing radiation – reliably for study after study.
- 生理监测是摩西班的设计中心in vivo scanners, not an add-on. High quality video, breathing monitoring by video-movement and pressure, ECG and thermostat-controlled warming, support in vivo cardiac-lung studies with minimized welfare impact on the animal
- Advanced animal cassettes connected for full physiological monitoring and anesthesia provision yet detachable with a single locking button – the universal Bruker in vivo bed. Support for third party devices such as ventilators (e.g. Scireq FlexiventTM值).
- 全面的时间门控解决方案：前瞻性和回顾性，基于时间和图像的内在门控。连续旋转可用于快速低剂量门控扫描。
- Full in-house software solution for cardiac function analysis in 4D: ejection volume, other cardiac chambers and aorta, time-analysis of cardiac wave-train including regularity and fractality, with flexible segmentation and analysis of the cardiac cycle in CT-Analyser software.
Application Gallery
Volume rendered 3D model of a femur with color-coded representation of the trabecular thickness, scanned at 2.8 μm pixel size.
3D model of a rat skull, scanned at 20µm voxel sizein vivo.
Volume rendered 3D model of a mouse knee, scanned at 6 µm voxel sizein vivo.
3D representation of the mouse vasculature, scannedin vivoat 7 µm voxel size after a bolus injection of vascular contrast agent.
Orthogonal cross-sections through the mouse lung scannedin vivo，显示肺部内血管和大型气道。
穿过小鼠体的横截面切片，以17 µm的体素尺寸扫描in vivowithout contrast agent injection.
通过小鼠肺横截面，扫描离体after chemical drying at 3 µm voxel size.
正交切片通过小鼠股骨，以2.8 µm的体素尺寸扫描。
Orthogonal slices through a mouse heart, scannedin vivoafter contrast agent injection.
小鼠肺的3D模型，使以绿色的肺肿瘤组织可视化。
사양
规格
SKYSCAN 1276 CMOS Specifications
Feature |
规格 |
益处 |
X-ray source |
40 – 100 kV, 20W < 5 µm spot size at 4 W 自动化的6位滤波器更换器 |
Maintenance-free sealed high resolution X-ray source |
X射线检测器 |
16 MPsCMOS detector (4096 x 4096 pixels) |
Fine-pitched detectors for achieving highest resolution |
空间分辨率 |
2.8µmsmallest pixel size 6µm空间分辨率（10％MTF） |
Highest true resolution for in vivo imaging |
| Object size | 直径75毫米 310毫米高 |
能够扫描大量样本量 |
方面 |
with ATS: 954mm W x 940mm H x 1190mm L (1560mm L with open specimen chamber), 330kg with LATS: 954mm W x 940mm H x 1340mm L (1740mm L with open specimen chamber), 450kg |
节省空间桌面系统，适合每个实验室 |
Power supply |
100-240V AC，50-60Hz，最大3A。 |
最低安装要求，标准电源就足够了 |
소프트웨어
位置，扫描，重建和分析
包括所有的软件需要t力量XRM解决方案o collect and analyze data. An intuitive graphical user interface with user guided parameter optimization support both expert and novice users. By using the latest GPU powered algorithms, reconstruction time is substantially reduced. CTVOX, CTAN and CTVOL combine to form a powerful suite of software for both qualitative and quantitative analysis of models.
测量软件：
Skyscan 1276 CMOS版 - 仪器控制，测量计划和收集
重建软件：
NRECON – Transforms the 2D projection images into 3D volumes
Analysis Software:
DATAVIEWER- 逐片检查3D卷和2D/3D图像注册
CTVOX– Realistic visualization by volume rendering
CTAN- 2D/3D图像分析与处理
ctvol– Visualization of surface models to export for CAD or 3D printing
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