Rapiflex®
Analysis Speed
Results within minutes
命运
Bruker’s market leading MALDI-TOF system
características
MALDI-TOF/TOF为蛋白质表征增添了独特的功能
With speed in mind, we designed the heart of the rapifleX® MALDI Imaging solution to work up to 20 times faster than traditional MALDI-TOF systems, to meet the increasing requirements of tissue imaging or high-throughput primary screening.
适应性的离子光学和类领先的激光技术可提供最佳的数据质量，而不管采集模式或质量范围如何。
The unprecedented 10 kHz speed and ion source robustness, the wide dynamic range, higher specificity and resolution, all contribute to the detailed
characterization of biologically and clinically relevant lipids, peptides and proteins, raising customer MALDI-TOF/TOF expectations for applications such as:
- MALDI Imaging
- MALDI PharmaPulse high-throughput screening
- 深入的蛋白质表征
受益
最先进的技术符合高级信息学
The rapifleX®combines state-of-the-art technology with advanced informatics into a system that gives you speed, robustness, versatility and confidence. The platform offers a complete characterization system with unprecedented speed of analysis and performance.
速度- highest throughput provides 5-20 times increase in speed
坚固- User removable ion source for easy cleaning, designed for maximum uptime in 24/7 operations
Confidence
- Ion optics adapt to application
- No compromise, maximum resolution for full molecular weight range
- Maximized sensitivity for MS and MS/MS analysis
- 大型肽，例如糖肽，DI/Trisulfide肽和困难的非特里氏肽的MS/MS质量范围
- Superior resolution for high selectivity in complex mixtures
- 至高的前体离子选择MS/MS数据质量的信心
- High dynamic range
- 组织成像（scils™ Lab )
- Pharma QC工作流（生物制药指南针®)
- Polymer research (PolyTools)
- Ultra high-throughput screening (MALDI PharmaPulse®)
Aplicações
MALDI MS/MS性能在新级别：质量范围为M/Z 8000
MALDI provides single charged ions and fragment ions of molecules that are difficult to analyze using ESI. Non-tryptic peptides can be well analyzed by MALDI MS/MS. Spectra that are otherwise difficult to analyze and inspect can be easily interpreted, such as MS/MS spectra of glycopeptides or disulfide/trisulfide linked peptides. Top-Down spectra of proteins as large as intact antibodies can be automatically interpreted.
MS/MS糖肽分析
糖肽分析是重组抗体质量控制的重要步骤。在质量范围内的高前体选择分辨率和同位素解析的片段可以表征非特殊或疏水性肽。MALDI分析的速度可为您的生产工作流提供更快的批次发布。
可用的最佳自上而下和中倒数分析：在完整蛋白的最短分析时间获得最高的序列覆盖率
Top-down sequencing at a new level: optimized MALDI laser for high performance top-down protein sequencing and the high resolution provide for unmatched sequence analysis of intact proteins. Terminal modification status and sequence assessment, full protein sequence confirmation and sequence error curation are usual applications.
MS/MS用于蛋白质序列验证
具有出色序列覆盖的蛋白质的自上而下的测序，可以明确鉴定修饰，例如通过LC-MALDI二硫化物/三硫化物分析和突变位点。
加速药物发现和筛查
新的Rapiflex®MALDI PharmaPulse®is the first solution to offer the speed, specificity and robustness required for large primary screens in drug discovery:
- 集成的自动化解决方案可以在不到9分钟的时间内处理1536个目标板〜0.3秒/样品
- 比多义LC/SPE-MS系统少100倍
- 无需SPE墨盒或HPLC柱
- 无标签检测加速并简化了测定开发，并避免了伪像的干扰
- 检测所需的极低样品体积（通常约为1μl）可实现单个良好动力学读数，这可以减少所需的测定总数
放松和速度进行组织
TheRapiflex®MALDI Tissuetyper®is the complete solution for MALDI Imaging.
- 最快的收购最多40像素/秒
- Superior image quality
- Integration of histology
- Comprehensive software for the interpretation of large tissue-based biomarker studies
软件
网络研讨会
相关网络研讨会
Testemunhos
"In our lab, with its high MS2分离效率、分辨率和质量准确性at high m/z values, the rapifleX TOF/TOF has been instrumental in identifying and characterizing new subunits of membrane protein complexes, including prokaryotic respiratory chain complexes and antibiotic drug targets."
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For Research Use Only. Not for use in clinical diagnostic procedures.