Metabolomics

Metabolomic analysis must accurately determine even the slightest changes of molecular profile related to disease, disease progression, therapeutic intervention, genetic modification or environmental variation.

Disease, drugs, or environmental variation can perturb concentration and fluxes in intermediary metabolic pathways. These responses involve adjustment of intracellular and extra cellular environments in order to maintain homeostasis. Both perturbation and adjustment are expressed as changes in the normal

patterns in cells and biofluids that are characteristic (a "fingerprint") of the nature of the site of the action. These patterns can be evaluated using spectroscopic / spectrometric techniques combined with multivariate statistical methods to gain insight into the molecular response of a biological system.

To determine functions of “unknown” genes in functional genomics studies, Metabolomics has gained increasing attention since changes in small molecule concentrations are closely related to the observed phenotype.

Thanks to our latest innovations inNMR,LC-MSandGC-MStechnologies, Bruker remains the leader in integrated solutions for metabolomics.

Our systems can be used for a broad variety of targeted andnon-targeted metabolomicsstudies. They are very well equipped to detect, identify, and measure metabolome molecules covering the entire metabolomics chemical space. Thus,

Bruker provides all hardware and software “puzzle pieces” to give a complete picture of the metabolome.If you want to know more about our metabolomics solutions make sure to visit our pages on theMetaboScape^®andMetabolomics Spectral Libriaries.